Other experts say there is simply no conclusive evidence at this point that titanium dioxide is damaging to humans after ingesting. Kaminski in particular said the research studies cite health hazards that were found by using high doses of the product, which you would not normally see in food.

As of August 7, the use of titanium dioxide in food is banned in the European Union. Europe is taking a precautionary principle approach based on findings from the European Food Safety Authority (EFSA).

TiO₂ NPs appeared to be more toxic to nematode Caenorhabditis elegans than submicron-sized TiO_2.  At a concentration of 1 mg/l, 7 nm particles affected its fertility and survival rate and were more toxic than 20 nm anatase particles. Similarly, Hu et al. showed that rutile particles (10–20 nm), at concentrations above 1 g/kg soil, can be bio-accumulated in earthworms, where they induce oxidative stress, inhibit the activity of cellulase and induce DNA and mitochondrial damage.

Some people have concerns about the safety of titanium dioxide because of reports linking it to cancer.

Drivers

As a food additive, titanium dioxide and its nanoparticles in particular have been associated with DNA damage and cell mutations, which in turn, have potential to cause cancer. When used as a food coloring, it is known as E171.

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North America

Titanium dioxide is typically micronized and coated for use in cosmetics products. The micronizing makes this somewhat heavy-feeling ingredient easier to spread on skin, plus a bit more cosmetically elegant. Micronized titanium dioxide is much more stable and can provide better sun protection than non-micronized titanium dioxide.

Titanium dioxide is an important chemical compound that is widely used in various applications, including paint, cosmetics, sunscreens, and food coloring. As the demand for this versatile substance continues to grow, the role of titanium dioxide manufacturers becomes crucial in ensuring a stable supply for industries around the world.

In addition to consistency, manufacturers must also consider the cost implications of buff percentage. Higher levels of coating on titanium dioxide particles can increase production costs, as more coating materials are required. However, a lower buff percentage may lead to a lower quality product that does not meet the needs of customers. Balancing the cost and quality considerations of buff percentage is a key challenge for manufacturers in the titanium dioxide industry.