In addition to quality, CAS 13463-67-7 also places a strong emphasis on sustainability. The factory is dedicated to reducing its environmental impact by implementing eco-friendly practices and technologies. From waste reduction to energy efficiency, CAS 13463-67-7 is constantly looking for ways to improve its sustainability and contribute to a greener future.

In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

Food safety experts in the European Union (EU) have recently updated their safety assessment of TiO₂ as a food additive. In Europe, TiO₂ is referred to as E171, in accordance with European labelling requirements for food additives. The EU expert panel took into account toxicity studies of TiO₂ nanoparticles, which to this point had not been considered relevant to the safety assessment of TiO₂ as a food additive.  

Despite its many advantages, the production of lithopone is not without its challenges. The raw materials used to make lithopone, particularly zinc sulfide, can be expensive and difficult to source. In addition, the production process itself can be complex and energy-intensive, requiring specialized equipment and skilled workers to operate. As a result, lithopone manufacturers must carefully manage their operations to ensure they remain competitive in the market.

Fig. 4. Hemolysis (%) values of samples, A: 0.2 mg/mL P25TiO₂NPs; B: 0.02 mg/mL P25TiO₂NPs; C: 0.2 mg/mL VitaminB2@P25TiO₂NPs; D: 0.02 mg/mL VitaminB2@P25TiO₂NPs after 3 h of irradiation (red) and 6 h (blue). SD <5 for all samples and p <0.05 between C-D and A-B.

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